University of Southern California

Crump Lab

USC Stem Cell


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Broad Fellow Joanna Smeeton fishes around for stem cell-based treatments for arthritis

USC Stem Cell scientist Joanna Smeeton knows what arthritis can do to people: she’s witnessed the annual exodus out of her native country of Canada during the winter months. As this year’s Broad Fellow, she is exploring stem cell-based approaches […]

Bone defects inspire perfect union between surgeon-scientist and stem cell researchers at USC

As chair of the Department of Orthopaedic Surgery at the Keck School of Medicine of USC, Jay R. Lieberman regularly sees patients with bone defects too severe to heal. This unmet clinical need inspired him to team up with two […]

Gage Crump, Yang Chai and Rob Maxson receive $3.3 million NIDCR grant

With craniosynostosis—a birth defect estimated to occur in roughly one out of every 2,500 live births—the fibrous joints (or sutures) fuse together prematurely, leaving the cranium little room to expand to accommodate the growing brain. In a mild case, this […]

What I’m reading: Gage Crump and Andy McMahon offer top picks

Gage Crump: In the latest issue of Science Translational Medicine, Katja M. Heinemeier and coauthors use “bomb pulse” labeling to provide new insights into cell turnover in our joints. This technique takes advantage of the temporary high radiation levels in […]

ELife study describes how arthritis originated in primordial fish

We all know someone affected by arthritis—as well as that old dog down the block. But according to a new study in eLife, arthritis is much more widespread in the animal kingdom than previously suspected. In the study, Amjad Askary […]

Lindsey Barske wins NIH Pathway to Independence Award

Years ago, Lindsey Barske pulled on a pair of tall rubber boots and began a journey that led from her college research experience on the muddy Alaskan tundra to her current postdoctoral studies in the USC Stem Cell lab of […]

Development study uses zebrafish to understand the role of cartilage in bone repair

Scientists have long believed that the processes required for embryonic development are recapitulated during the regeneration of damaged body parts, such as fractured bones. In a new study published in Development, USC Stem Cell researchers Sandeep Paul, Simone Schindler and […]

Lab publishes study on how skeletal stem cells form the blueprint of the face

Timing is everything when it comes to the development of the vertebrate face. In a new study published in PLoS Genetics, USC Stem Cell researcher Lindsey Barske from the laboratory of Gage Crump and colleagues identify the roles of key […]

Lab’s study on cover of Developmental Cell

Arthritis, the leading cause of disability in the U.S., involves the loss of a special type of cartilage cell lining the joints. In a study appearing on the cover of the latest issue of Developmental Cell, first author Amjad Askary […]

Lindsey Mork and Michaela Patterson win Doerr Stem Cell Challenge Grant

Congratulations to Lindsey Mork, whose collaborative proposal with Michaela Patterson won a Doerr Stem Cell Challenge Grant. Together, they will use zebrafish to investigate the role of the gene Tnni3k in heart regeneration. When activated, this gene appears to lower […]